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Endogenous SAgs [modify] Small lymphocyte stimulating (Mls) exotoxins were initially found in the thymic stromal cells of mice. These contaminants are encoded by SAg genes that were integrated into the mouse genome from the mouse mammary tumour virus (MMTV). The existence of these genes in the mouse genome enables the mouse to reveal the antigen in the thymus as a way of adversely picking for lymphocytes with a variable Beta region that is prone to stimulation by the viral Droop.

Similar endogenous SAg-dependent selection has yet to be recognized in the human genome, however endogenous Droops have been discovered and are believed of playing an essential role in viral infection. Infection by the Epstein, Barr virus, for example, is known to trigger production of a Droop in contaminated cells, yet no gene for the toxic substance has been found on the genome of the virus.

Staphylococcus aureus and its IgE-inducing enterotoxins in asthma: current  knowledge - European Respiratory Society

Comparable results have been found with rabies, cytomegalovirus, and HIV. Referrals [edit] Llewelyn M, Cohen J (March 2002). "Superantigens: microbial agents that corrupt immunity". Lancet Infect Dis. 2 (3 ): 15662. doi:10. 1016/S1473 -3099( 02 )00222-0. PMID 11944185.  sjögren's syndrome muscle wasting , Llera A., Malchiodi E.L., Mariuzza R.A. The structural basis of T cell activation by superantigens.

Rev. Immunol. 1999; 17:435466. doi: 10. 1146/annurev. immunol. 17. 1.435. Sriskandan S, Faulkner L, Hopkins P (2007 ). "Streptococcus pyogenes: Insight into the function of the streptococcal superantigens". Int. J. Biochem. Cell Biol. 39 (1 ): 129. doi:10. 1016/j. biocel. 2006. 08.009. PMID 17029999. Mehindate K, Thibodeau J, Dohlsten M, Kalland T, Skaly RP, Mourad W (November 1995).

Superantigen - Wikipedia

Excitement About Identification and Characterization of Novel Superantigens

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